Start date: 2023
Award: £48,419
Status: Complete
What was the issue addressed by this study?
Crohn’s disease occurs when the immune system within the intestine starts reacting to the harmless bacteria that live alongside it as if they were a threat. In many ways, it is surprising that we all don’t develop this disease as the immune system lives side-by-side with huge numbers of intestinal bacteria in all of us. To prevent this reaction occurring, the immune system produces chemicals such as IL-10 that reduce these responses.
We do not fully understand why some people develop Crohn’s disease, but past research has shown that certain immune cells become “reprogrammed” to stop responding to IL-10, increasing inflammation and contributing to the symptoms of Crohn’s.
Although all cells have the same genes within them, the genes are switched on (expressed) and off though a process called epigenetics. The research team have found that the genes expressed by monocytes in Crohn’s disease are quite different to those from healthy people, suggesting that this reprogramming has wide-ranging effects on the activity of these cells.
What was the aim of this study?
The research team wanted to understand this epigenetic reprogramming of immune cells called monocytes in Crohn’s disease and in particular how it contributes to an inability to respond properly to IL-10. The team examined samples taken from patients recently diagnosed with Crohn’s disease who had not yet started drug treatment. They found changes in how DNA is expressed in monocytes gathered from patients with Crohn’s, discovering new pathways of how the disease develops and therefore potential new strategies for treatment.
The research team
This project is led by Dr Andrew Stagg at Queen Mary University of London. Watch the video to below to hear from Dr Stagg about why this research is important: